منابع مشابه
Melatonin and postoperative delirium: a possible link?
To the Editor, Melatonin, an indole neurohormone, is the principal secretory product of the pineal gland that is synthesized from tryptophan and released directly into the bloodstream in a circadian pattern governed by the light and dark cycle. It produces hypnotic effects by accelerating sleep initiation and improving sleep maintenance and efficiency. Unlike most hypnotics, melatonin is not as...
متن کاملMelatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol
BACKGROUND Delirium is a syndrome characterized by acute fluctuations and alterations in attention and arousal. Critically ill patients are at particularly high risk, and those that develop delirium are more likely to experience poor clinical outcomes such as prolonged duration of ICU and hospital length of stay, and increased mortality. Melatonin and melatonin agonists (MMA) have the potential...
متن کاملNeural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI.
Despite the significant impact of postoperative delirium on surgical outcomes and the long-term prognosis of older patients, its neural basis has not yet been clarified. In this study we investigated the impact of premorbid brain microstructural integrity, as measured by diffusion tensor imaging before surgery, on postoperative delirium incidence and severity, as well as the relationship among ...
متن کاملLoss of melatonin daily rhythmicity is asociated with delirium development in hospitalized older adults
Delirium is associated with circadian rhythm disruption. In this study we have explored whether circadian variation of melatonin is an indicator for delirium. Melatonin levels were determined from the first day of hospitalization and up to three days after the onset of delirium. Patients who did not developed delirium exhibited a daily melatonin rhythm, while in patients that developed delirium...
متن کاملMelatonin and the Prevention and Management of Delirium: A Scoping Study
Background The therapeutic benefit of melatonin in the prevention and treatment of delirium is uncertain. Objective To perform a scoping study to describe the existing literature regarding the use of melatonin and ramelteon in the prevention and treatment of delirium. Methods We performed a scoping study using the Arksey and O'Malley framework to explore our objective. Two independent panel...
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ژورنال
عنوان ژورنال: Hospital Pharmacy
سال: 2013
ISSN: 0018-5787,1945-1253
DOI: 10.1310/hpj4805-378